منابع مشابه
Yeast Prions: Proteins Templating Conformation and an Anti-prion System
Most yeast prions (infectious proteins) are amyloids, linear β-sheet-rich polymers of a single protein with the β-strands perpendicular to the long axis of the filament. A single prion protein can form any of many different prion variants, differing in structure and biological properties, but with the same amino acid sequence. The folded in-register parallel β-sheet architecture we have shown f...
متن کاملPrions: Portable prion domains
Self-propagating abnormal proteins, prions, have been identified in yeast; asparagine/glutamine-rich 'prion domains' within these proteins can inactivate the linked functional domains; new prion domains and reporters have been used to make 'synthetic prions', leading to discoveries of new natural prions.
متن کاملPrions and prion-like proteins.
Prions are self-replicating protein aggregates and are the primary causative factor in a number of neurological diseases in mammals. The prion protein (PrP) undergoes a conformational transformation leading to aggregation into an infectious cellular pathogen. Prion-like protein spreading and transmission of aggregates between cells have also been demonstrated for other proteins associated with ...
متن کاملYeast Prions and Their Prion-Forming Domain
The focus of research on yeast prions is now moving to exploit this established and highly tractable model system to elucidate the molecular basis of prion conversion and to extrapolate these findings to mammalian prions. This of course raises the question of whether United Kingdom such extrapolation is valid. Yeast and Mammalian Prion Conversion: A Common Mechanism? Over a period of some 25 ye...
متن کاملSilent Prions and Covert Prion Transmission
Prions are infectious agents with zoonotic potential that cause progressive neurodegenerative diseases, known as the transmissible spongiform encephalopathies (TSEs), in animals and humans. Prion disease can be initiated by a spontaneous event, handed down within families from generation to generation through genetic inheritance, or transmitted between susceptible hosts via direct exchange of b...
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ژورنال
عنوان ژورنال: Nature Reviews Neurology
سال: 2017
ISSN: 1759-4758,1759-4766
DOI: 10.1038/nrneurol.2017.100